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Barr Bodies: heterochromatinized X-chromosomes In mammals, males are heterogametic (XY) and females homogametic (XX). Dosage compensation is achieved by inactivation at random of one of the two X chromosomes. The heterochromatized X chromosome appears as a darkly-staining bodies attached to the nuclear membrane. The phenomenon was first described by Dr Murray L. Barr, a Canadian cytogeneticist, and heterochromatin bodies are now called Barr Bodies. [The other dark bodies within the nucleus are nucleoli, which represent repetitive rDNA genes]. Barr body testing was introduced in the 1966 Olympic games, in an effort to detect male atheletes trying to “pass“ as females, to gain a competitive advantage. Teams from eastern Europe wer particularly suspect. Such allegations had been made for many years, and a number of athletes were stripped of their medals as a result of ambiguous genital sex. Cytological testing apparently never detected deliberate fakery. It did however detect a number of cases of testicular feminization syndrome (TFS), a genetic condition in which an XY (male) zygote develops as a phenotypically female adult, due to failure of androgen receptors. Such individuals would test positive for the presence of a Barr body. It appears that in most if not all cases, the athletes were themselves unaware of their condition. #inheritance #geneticInformation #Inbreeding #Morphogenesis #TurnerSyndrome #AminoAcids #chromatin #SisterChromatid #breedingExperiment #lawOfProbability #doubleStrandedDNA #NaturalSelection #viruses #punnettSquare #cytosine #FrancisCrick #hardyWeinbergPrinciple #PCR #ChromosomeArm #CellCulture #DaughterCells #TumorCells #hardyWeinbergEquilibrium #Nucleotide #Diploid #population #centromere
