Sodium Regulation: Proximal Convoluted Tubule

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21 May 2022

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This lesson explores how sodium is regulated along the proximal convoluted tubule (PCT). It focuses on the transcellular and paracellular pathways, driving forces, the role of the sodium-cotransporters and the sodium/hydrogen exchanger (NHE3), and carbonic anhydrase. It also discusses how acetazolamide acts as a diuretic by inhibiting NHE3-dependent sodium reabsorption. For help preparing for an exam on this and other topics, visit

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