Sodium Regulation: Thick Ascending Limb

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21 May 2022

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This lesson explores how sodium is regulated along the thick ascending limb (TAL). In particular, the role of the sodium, potassium, 2 chloride cotransporter (NKCC2), the sodium/hydrogen exchanger (NHE3), the paracellular pathway, driving forces, and how genetic mutations and loop diuretics affect sodium reabsorption. For help preparing for an exam on this and other topics, visit

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