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Chargaff's rules state that in the DNA of any species and any organism, the amount of guanine should be equal to the amount of cytosine and the amount of adenine should be equal to the amount of thymine. Further a 1:1 stoichiometric ratio of purine and pyrimidine bases (i.e., A G=T C) should exist. This pattern is found in both strands of the DNA. They were discovered by Austrian-born chemist Erwin Chargaff, in the late 1940s. First parity rule The first rule holds that a double-stranded DNA molecule, globally has percentage base pair equality: A% = T% and G% = C%. The rigorous validation of the rule constitutes the basis of Watson-Crick pairs in the DNA double helix model. Second parity rule The second rule holds that both Α%≈ Τ% and G% ≈ C% are valid for each of the two DNA strands. This describes only a global feature of the base composition in a single DNA strand. Questions: The molecule shown at the right is a ______a________. A) Purine ribonucleotide monophosphate B) Pyrimidine deoxynucleotide monophosphate C) Pyrimidine dideoxynucleotide monophosphate D) Purine deoxynucleotide monophosphate E) Pyrimidine ribonucleotide monophosphate If a piece of double stranded DNA has a guanine content of 26%, what proportion of thymine do you expect? A) 24% B) 25% C) 26% D) 0% E) 48% #NikolaysGeneticsLessons #palindromicSequence #protein #ChargaffsRule #pyrimidine #purine #guanine #cytosine #adenine #Genetics #dnaReplication #chargaffsRuleOfDna #chargaffsRuleProblems #watsonAndCrick #chargaffsRuleExplained #dnaBasesPairing #complementaryBasePairing #DNASequence #dnaComplementarySequence #dnaSequenceComplementaryStrand #andThymine #dnaSemiConservativeReplication #ReplicationFork #dnaTranscription #initiation
