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Opetaia was scheduled to challenge the reigning IBF, The Ring and lineal cruiserweight champion Mairis Briedis on 6 April 2022. The bout was postponed on February 16, as Briedis tested positive for COVID-19. The bout was rescheduled for 11 May, and was expected to take place at the Gold Coast Convention and Exhibition Centre in Broadbeach, Queensland, Australia. The bout was once again postponed on April 8, as Opetaia suffered a rib injury, and rescheduled for July 2. Opetaia won the fight by unanimous decision, with scores of 116–112, 116–112 and 115–113. During the fight, Opetaia badly broke his jaw in two places. Unable to give an interview following the match, he was instead taken directly to the hospital to undergo surgery to repair the fractures
