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In this video, we characterize NBOMe positional isomers as serotonergic psychedelics through interaction with 5-HT 2A receptor and their impact on downstream signaling. Serotonergic psychedelics are increasingly being recognized for their therapeutic benefit, but key structure-activity relationships remain largely unknown. Asher Brandt takes us through his work in describing these relationships through docking experiments through Nanome's AutoDock Smina plugin as well as experiments published in his previous work. Thank you to our collaborators Asher Brandt, Molecular Pharmacologist at the University of Saskatchewan, Canada. Pottie et al. (2021). Serotonin 2A Receptor (5-HT 2A R) Activation by 25H-NBOMe Positional Isomers: In Vitro Functional Evaluation and Molecular Docking. ACS Pharmacol. Transl. Sci. 4, 479–487. DOWNLOAD NANOME FOR FREE Oculus: Steam: Viveport: SideQuest: SUPPORTED VR HEADSETS Oculus Rift Oculus Quest HTC Vive Complete list: CONNECT WITH US Twitter: LinkedIn: Facebook: Instagram: ABOUT NANOME Website: Step into Nanome and experience the world at the molecular level. From drug discovery to chemistry class, Nanome is a powerful tool for research and education. Visualize, design, and simulate chemical compounds, proteins, and nucleic acids like never before. Collaborate remotely in real-time, save workspaces, and share. Leading pharmaceutical and biotech companies use Nanome to accelerate drug discovery and collaborate with distributed teams across the globe. Educators at top universities use Nanome to teach chemistry in virtual reality, allowing students to explore shapes of proteins and drug compounds and to learn how these structures explain function. Be sure to also check out our blockchain platform, Matryx, which will serve as the backend IP tracking mechanism for Nanome. More info at
