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Definition CRS is a syndrome characterized by inflammation of the nasal passages and sinuses that results in persistent or recurrent nasal discharge and sneezing and that defies specific etiologic diagnosis. Although CRS is encountered with some frequency, estimates of incidence and prevalence are lacking. Signalment Cats of any breed or age and either gender may be affected. By definition, the cause of CRS is undetermined. Efforts must be made to rule out specific causes of nasal discharge and associated clinical signs. Cats with previous respiratory viral infection may be at greater risk. The pathophysiology of CRS is not understood. Previous viral respiratory infection may predispose to CRS. FHV-1 (also called rhinotracheitis) and FCV are common causes of acute upper respiratory tract infection in kittens and naïve cats. Although acute infection is typically self-limiting, FHV-1 is not cleared; instead, cats become latent carriers. Similarly, cats may remain carriers of FCV
