The use of botulinum toxin for the treatment of wrinkles has become very popular in recent years. The botulinum toxin is produced by the Clostridium botulinum bacterium and causes muscle relaxation by inhibiting a chemical substance called Acetylcholine, in the junction between nerve and muscle (neuromuscular plate). It has been used since the 80s for the treatment of neurological and ophthalmic diseases with uncontrolled or excessive muscle contraction. The use of the botulinum toxin in cosmetic began in
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