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In this video, we discuss a new drug from a biotech company called Biogen that was just recently approved by the FDA for treating Alzheimer’s Disease. It’s the first drug cleared by the FDA to slow cognitive decline in people living with Alzheimer’s and the first new medicine for the disease in nearly two decades. The FDA’s decision was controversial but in our video we’re only going to discuss the mechanism of action of this drug, which goes by the name aducanumab. Aducanumab targets a “sticky” compound in the brain known as beta-amyloid, which most scientists expect plays a role in the devastating disease. Biochemical and structural analyses show that aducanumab binds a linear epitope formed by amino acids 3–7 of the beta amyloid peptide. The crystal structure of the Fab fragment of aducanumab bound to its epitope peptide reveals that aducanumab binds to the N terminus of beta amyloid in an extended conformation, distinct from those seen in structures with other antibodies that target this epitope. Reference: Arndt et al. (2018). Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β. Nat Sci Rep, 8:6412. DOI: DOWNLOAD NANOME FOR FREE Oculus: Steam: Viveport: SideQuest: SUPPORTED VR HEADSETS Oculus Rift Oculus Quest HTC Vive Complete list: CONNECT WITH US Twitter: LinkedIn: Facebook: Instagram: ABOUT NANOME Website: Step into Nanome and experience the world at the molecular level. From drug discovery to chemistry class, Nanome is a powerful tool for research and education. Visualize, design, and simulate chemical compounds, proteins, and nucleic acids like never before. Collaborate remotely in real-time, save workspaces, and share. Leading pharmaceutical and biotech companies use Nanome to accelerate drug discovery and collaborate with distributed teams across the globe. Educators at top universities use Nanome to teach chemistry in virtual reality, allowing students to explore shapes of proteins and drug compounds and to learn how these structures explain function. Be sure to also check out our blockchain platform, Matryx, which will serve as the backend IP tracking mechanism for Nanome. More info at
