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Nick Norwitz, PhD and Harvard Medical student, showed he can lower his LDL cholesterol twice as much with Oreo cookies compared to statins. Since Nick is a lean mass hyper-responder (LMHR) following a ketogenic diet, he sought to demonstrate how LDL lowering may not always be the ultimate goal, especially if you get there with Oreos! But what does this mean for how we see LDL, and how it might impact the understanding of LMHRs? Many LMHRs follow the ketogenic diet as a medical intervention to treat conditions such as diabetes or mental disorders. Based on the “lipid energy model,” we can hypothesize that LDL elevations may not have the same impact on someone who is an LMHR. The results of Norwitz’s provocative experiment serve as a call to action for further scientific investigation to help patients weigh risks and benefits when pursuing treatment options. Link to the Oreo Study: Oreo Cookie Treatment Lowers LDL Cholesterol More Than High-Intensity Statin therapy in a Lean Mass Hyper-Responder on a Ketogenic Diet: A Curious Crossover Experiment Nick Norwitz - Twitter @nicknorwitz YouTube @nicknorwitzPhD Other studies mentioned: Elevated LDL Cholesterol with a Carbohydrate-Restricted Diet: Evidence for a “Lean Mass Hyper-Responder” Phenotype About us: Metabolic Mind™ is a nonprofit initiative incubated by Baszucki Group. Our mission is to provide education and resources in the emerging field of metabolic psychiatry, including ketogenic interventions for mental disorders. Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications. Timestamps: 0:00 Introduction 2:34 How the Oreo & LDL study was conducted 3:58 Results of the Oreo & LDL study 5:14 Why did Dr. Norwitz conduct the Oreo study? 8:46 What isn’t the Oreo study? 10:42 What will people take away from the Oreo study? 15:30 Will people conclude that Oreos are healthy? 17:00 How can this study be applied to the general population? 19:10 A call to engage with the scientific community 20:48 How this study can be applied to a clinical setting 25:37 Current body of evidence on high LDL for lean mass hyper-responders 27:29 Risks vs benefits of keto for lean mass hyper-responders 30:02 How Dr. Norwitz felt while eating Oreos and on statins 35:42 What is next for Dr. Norwitz? And how can you help? #MetabolicMind #KetoForMentalHealth #MetabolicPsychiatry #MetabolicNeuroscience #KetogenicMetabolicTherapy #LeanMassHyperResponder #LDL #Cholesterol #LMHR #LipidEnergyModel #NutritionalKetosis #KetoDiet
