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Hardy-Weinberg Principle of Equilibrium The Hardy-Weinberg Principle states that a population's allele and genotype frequencies will remain constant in the absence of evolutionary mechanisms. Ultimately, the Hardy-Weinberg Principle models a population without evolution under the following conditions: no mutations, no immigration/emigration, no natural selection, no sexual selection, and a large population. Although no real-world population can satisfy all of these conditions, the principle still offers a useful model for population analysis. Hardy-Weinberg Equations and Analysis According to the Hardy-Weinberg Principle, the variable p often represents the frequency of a particular allele, usually a dominant one. For example, assume that p represents Y for yellow pea pods. The variable q represents the frequency of the recessive allele, or y for green pea pods. If p and q are the only two possible alleles for this characteristic, then the sum of the frequencies must add up to 1, or 100 percent. We can also write this as p q = 1. If the frequency of the Y allele in the population is 0.6, then we know that the frequency of the y allele is 0.4. From the Hardy-Weinberg Principle and the known allele frequences, we can also infer the frequencies of the genotypes. Since each individual carries two alleles per gene (Y or y), we can predict the frequencies of these genotypes with a chi square. If two alleles are drawn at random from the gene pool, we can determine the probability of each genotype. In the example, our three genotype possibilities are: pp (YY), producing yellow peas; pq (Yy), also yellow; or qq (yy), producing green peas. The frequency of homozygous pp individuals is p2; the frequency of hereozygous pq individuals is 2pq; and the frequency of homozygous qq individuals is q2. Again, if p and q are the only two possible alleles for a given trait in the population, these genotypes frequencies will sum to one: p2 2pq q2 = 1 (Figure 1). In our example, the possible genotypes are homozygous dominant (YY), heterozygous (Yy), and homozygous recessive (yy). If we can only observe the phenotypes in the population, then we know only the recessive phenotype (yy). For example, in a garden of 100 pea plants, 86 might have yellow peas and 16 have green peas. We do not know how many are homozygous dominant (Yy) or heterozygous (Yy), but we do know that 16 of them are homozygous recessive (yy). Therefore, by knowing the recessive phenotype and, thereby, the frequency of that genotype (16 out of 100 individuals or ), we can calculate the number of other genotypes. If q2 represents the frequency of homozygous recessive plants, then q2 = . Therefore, q = 0.4. From p q = 1, we know that p = 0.6. The frequency of homozygous dominant plants is or 36 out of 100 individuals and the frequency of heterozygous plants is or 48 out of 100 plants. Applications of Hardy-Weinberg The genetic variation of natural populations is constantly changing from drift, mutation, migration, and natural and sexual selection. The Hardy-Weinberg Principle gives scientists a mathematical baseline of a non-evolving population to which they can compare evolving populations. If the numbers differ dramatically from the value expected from the Hardy-Winberg equation, scientists can hypothesize about the mechanisms driving the population's evolution. #aminoAcids #genes #genetics #FrancisCrick #GeneticsLecture #geneticDrift #hardyWeinbergPrinciple #breedingExperiment #breeding #cytosine #BloodType #Cancer #DNA #gene #chromosome #CellCulture #Autosomal #inbreeding #genotype
