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Charcot-Marie-Tooth disease is a group of progressive hereditary nerve disorders associated with defective production of proteins in peripheral nerves or myelin. The disease is inherited in an autosomal dominant fashion, and the most common mutation is caused by a duplication of the gene, PMP22. Clinical findings to know about include sensory and motor deficits, and foot deformities including hammer toe, pes cavus (high-arched foot), pes planus (flat foot), and foot drop. Nerve damage and resulting muscle a
