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On 25 January 2022, Edwards' promoters MTK Global announced that he would make the second defense of his title against the one-time IBF title challenger Muhammad Waseem, who was at the time the #3 ranked IBF flyweight contender. The fight was booked for 23 March 2022, and took place at the Aviation Club Tennis Centre in Dubai, United Arab Emirates. Two weeks later, on 9 February, Edwards signed a promotional deal with Probellum. Edwards won the fight by unanimous decision. Two of the judges scored the bout 115–111 in his favour, while the third judge awarded him a 116–110 scorecard. Waseem was deducted a point in both the sixth round for holding and a point in the seventh round for headbutting. Edwards called for a title unification bout with Julio Cesar Martinez in his post-fight interview, stating: “I want The Ring Magazine, I want the WBC“.
