NextGEN CRISPR Genome Engineering -- Clean Genome Editing without Off Target Mutati

he CRISPR-Cas9 system has gained popularity due to its simplicity and high efficiency. However, the CRISPR technology has been plagued by problems with off-target mutations, a concern for research and drug discovery applications as it may compromise results. NextGEN™ CRISPR technology, developed by one of the members of Transposagen's Scientific Advisory Board (SAB), is the first truly dimeric RNA-guided FokI nuclease. NextGEN™ CRISPR technology has all the advantages of the CRISPR-Cas9 system, but has el