On September 21, 2021, the WBC ordered Gary Russell Jr. to defend his featherweight title against Magsayo. The title bout was scheduled as the main event of a Showtime broadcast card, which took place at the Borgata in Atlantic City, New Jersey on January 22, 2022. Despite being the underdog Magsayo won his first world title by majority decision. Two judges scored the fight 115–113 for Magsayo, while the third judge scored the fight as an even 114–114 draw. Magsayo ends Gary Russell's seven-year title reign and became the new WBC featherweight champion expressing his win saying “This is a dream come true,” “This was my dream since I was a kid, since I was an amateur. And now I’m champion. This is my dream.”
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