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On the 13th of March, 2021, Estrada faced WBA (Super) super flyweight champion, Román González in a highly anticipated rematch. This was the second time the pair had met. Their first fight in 2012 ended in a unanimous decision win for Gonzalez. Both fighters were throwing a lot of punches, with Compubox crediting both with 2529 thrown punches combined, making it the busiest fight at 115 pounds the company has ever tracked. In a very close and thrilling fight, Gonzalez seemed to have narrowly outlanded Estrada. However, Estrada earned the split-decision victory having two judges score the fight in his favor, 117-111 and 115–113, while the third judge had it 115-113 for Gonzalez
