González was booked to make his first light flyweight title defense against the one-time IBF mini flyweight title challenger Mark Anthony Barriga. The title fight headlined a ProBox TV show which took place in the Osceola Heritage Park in Kissimmee, Florida, on June 24, 2022. González retained the title by unanimous decision, with scores of 115–113, 115–113 and 117–111. Despite a slow start to the fight, during which time Barriga was able to successfully land counters, González began to take over as the fight went on, while Barriga faded late
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