Method development for targeted delivery of anticancer drugs

Victoria Shipunova – PhD, Senior research of Laboratory of molecular immunology, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences. Lecture in English. Oncological diseases is one of the most serious problems in biology and medicine - require diagnosis and intervention at the earliest stages of development, which is especially critical in the case of the development of aggressive metastatic tumors. To combat these diseases, chemotherapy drugs of a wide spectrum (not just targeting the tumor), such as doxorubicin, paclitaxel, methotrexate, and others, are traditionally used, which lead to a number of serious side effects. To reduce systemic toxicity and increase therapeutic efficacy, various types of combination therapies are often used, for example, combining chemotherapy, radiation therapy, cell therapy and / or immunotherapy. In addition, the effectiveness of treatment can be increased through the use of nanoparticles of different nature. They re