Comment regarding dominant-negative phenotype of the mutant with disrupted E3 Ubiquitin Ligase.

July 2022 “AT FRONTIERS” JOURNAL CLUB by Alex Sobko: Comment regarding “dominant-negative phenotype” of the mutant with disrupted RING Finger domain in E3 Ubiquitin Ligase. © Personal opinion, commentary, Alex Sobko, PhD © Design, record, edit, post at social media by Alex Sobko, PhD, 8762728, S-W IL ישראל References: Saraswathy VM, Kurup AJ, Sharma P, Polès S, Poulain M, Fürthauer M. The E3 ubiquitin ligase mindbomb1 controls planar cell polarity-dependent convergent extension movements during zebrafish gastrulation. Elife. 2022 Feb 10;11:e71928. Wall MJ, Collins DR, Chery SL, Allen ZD, Pastuzyn ED, George AJ, Nikolova VD, Moy SS, Philpot BD, Shepherd JD, Müller J, Ehlers MD, Mabb AM, Corrêa SAL. The Temporal Dynamics of Arc Expression Regulate Cognitive Flexibility. Neuron. 2018 Jun 27;98(6):. Sobko A, Ma H, Firtel RA. Regulated SUMOylation and ubiquitination of DdMEK1 is required for proper chemotaxis.