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Artificial Intelligence Doctor - This diagram illustrates how age-related beta cell changes contribute differently to insulin resistance versus prediabetes in elderly individuals. Let me explain the key differences: a) In insulin resistance: Beta cells initially compensate by increasing insulin production This compensation can temporarily mask glucose elevation The primary challenge is peripheral insulin resistance, not beta cell failure b) In prediabetes: Beta cell dysfunction becomes more prominent Insufficient insulin secretion leads to noticeable glucose elevation The transition to prediabetes occurs when beta cells can no longer compensate adequately Interplay and progression: The relationship between these conditions is dynamic: a) Continuum: Insulin resistance and prediabetes form a continuum in the progression towards type 2 diabetes Age-related beta cell changes influence the rate of this progression b)
