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Valladares was expected to challenge the reigning IBF mini flyweight champion Rene Mark Cuarto on 27 May 2022 in Monterrey, Mexico, in what was to be Cuatro's second title defense. The bout was later cancelled however, due to undisclosed reasons. The fight was later rescheduled for 1 July 2022, and took place at the same location and venue. Valladares won the fight by split decision. Two judges scored the fight 116–111 and 115–112 in his favor, while the third judge scored the bout 114–113 for Cuatro. Cuatro was deducted a point in the tenth round, for loose glove tape
