Breaking Barriers: The Total Synthesis of Palau'amine Explained (3D Visualization)

Dive into the world of advanced organic chemistry as we break down the total synthesis of Palau'amine, one of the most challenging targets for chemists. Discover how we overcame the obstacles presented by its complex structure, including its hexacyclic core and transazabicyclo[]octane substructure, through clear and engaging 3D animations. 🔬 In This Video: A detailed walkthrough of the Palau'amine synthesis process. Insights into the structural challenges and how they were addressed. The innovative strategies and methodologies used to achieve total synthesis. Whether you're a student, a researcher, or just passionate about chemistry, this video will enhance your understanding of organic synthesis and inspire you with the breakthroughs in the field. 👉 Watch now and join us on this journey of scientific discovery! Don't forget to like, comment, and subscribe for more cutting-edge chemistry content. ------------------------------------------------------------------------------------------------- Attributions: Vector graphics in this video Designed by Freepik. Source of the sound effects: ------------------------------------------------------------------------------------------------- References: K. C. Nicolaou, Jason S. Chen. Classics in Total Synthesis III: Further Targets, Strategies, Methods. Wiley-VCH. 2011 Ian B. Seiple, Shun Su, Ian S. Young, Chad A. Lewis, Junichiro Yamaguchi, and Phil S. Baran. Angew. Chem. Int. , 49, 1095 –1098 # ------------------------------------------------------------------------------------------------- Time code: 00:00 - Intro 00:14 - Origin of The Name 00:34 - Unprecedented Structure 01:23 - Retrosynthetic Analysis 01:33 - Late Stage Synthetic Strategy 01:43 - Macro Palau'amine 03:10 - Forward Synthesis 03:14 - Diels-Alder Cycloaddition 03:27 - Endo Selectivity 03:40 - Azide Displacement 03:56 - Deprotection 04:08 - Reprotection 04:16 - Ozonolysis 04:27 - Enolization 04:35 - Regioselective Halogenation 04:45 - Intramolecular Aldol Reaction 04:54 - Selective Chlorination 05:28 - Elimination 05:45 - Luche Reduction 06:08 - Spirocylization 06:49 - Regioselevtive C-H Functionalization 07:00 - Instaling Non-Spiro Guanidine Moiety 07:15 - Installation of Pyrrole 08:07 - Final Step