A 3D reconstructed forest of neurons

OIST researcher Hermina Nedelescu combines genetics, microscopy and computational anatomy to unravel the dense neuronal forest of Purkinje cells in the adult cerebellum. Purkinje cells are large neurons in the cerebellum, a part of the brain that plays a primary role in motor control. Purkinje cells form elongated branching structures called “dendritic trees“. To create this movie of multiple neighboring reconstructed “dendritic trees“, researchers used “Brainbow“ mice. These transgenic mice have had