Sanctum of domination is a major step up compared to Nathria, since it was balanced both for extra gear and for the domination shards. Don't even get me started on the first boss - that one will be a very serious challenge. But I skipped him to get to the second one. For the eye of the Jailer, the 12-minute Enrage is currently beatable. However, the hardest part are phases 2 and 3. For phase 2 - the eyes - you want to kill one eye as fast as possible, and the second one fast too. This is because you take a massive amount of damage from their AoEs and the Spreading Misery DoT. I was using the FD dispel legendary to minimize damage, and still barely mad it with 21% leeech and the Denathrius trinket. For phase 3, the dangerous ability is the tank nuke. For some reason he will cast in in phase 3 even if your pet is tanking, but not in phase 1. Anyways, if you FD the first and second cast, he will recast them after, but by delaying by a few seconds you can have him cast his beam
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