High ISO Sharpening in Adobe Camera Raw or Lightroom

For years I have received emails about the proper way to sharpen and reduce the noise in your photos.  Some people say sharpen at the end and do noise reduction at the beginning.  Others say to use the same parameters in presets for every image.  And some avoid the process altogether because it is not necessary. No matter how you look at it, Noise Reduction and Sharpening are a necessity when you shoot in RAW.  Your camera set to JPEG is going to do a great deal of both to make that picture look good.  However, in RAW, it is just RAW Data that has not undergone any filtration. In perfectly exposed images where the subject is in tack sharp focus and the ISO is low, noise reduction and sharpening are less important.  But there are times when you find that you must pinch out every ounce of aperture and increase that ISO way up just to snag a decent shot.  Should you miss it just because your ISO was high and your image isn't perfectly sharp?   No way! Last week I was out with Jim Welninski, he came out to vis