Making and Tasting the COLDEST Substance Known - Icilin

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3 Feb 2024

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Head to to save 10% off your first purchase of a website or domain using code CHEMIOLIS In this video I am making one of the coldest/iciest/mintiest substances known, Icilin. It is a super-agonist of the TRMP8 ion-channel which is a receptor on our mucous membranes that gives us the cold feeling from temperature and food such as mint. The compound is not found in nature and is fully synthetic, there are no other known natural compounds that induce a colder feeling. Supposedly the compound WS-12 should feel colder but is less potent, which I will make later to compare. Support my channel with patreon:

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