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*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]* Join the Physionic Insiders [Premium]: *JOIN THE COMMUNITY* Join my Community [It’s Free!]: *HIRE ME FOR CONSULTING:* *DONATIONS FOR A SCIENCE BASED CAUSE* Patreon: *WHERE ELSE IM ACTIVE:* Email: Podcast: Instagram: [1] Mohammed I, Hollenberg MD, Ding H, Triggle CR. A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan. Front Endocrinol (Lausanne). 2021;12:718942. Published 2021 Aug 5. doi: [2] Rena G, Hardie DG, Pearson ER. The mechanisms of action of metformin. Diabetologia. 2017 Sep;60(9):1577-1585. doi: Epub 2017 Aug 3. PMID: 28776086; PMCID: PMC5552828. [3] Herzig S, Shaw RJ. AMPK: guardian of metabolism and mitochondrial homeostasis. Nat Rev Mol Cell Biol. 2018;19(2):121-135. doi: [4] Harrison DE, Strong R, Sharp ZD, et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature. 2009;460(7253):392-395. doi: [5] Selvarani R, Mohammed S, Richardson A. Effect of rapamycin on aging and age-related diseases-past and future. Geroscience. 2021;43(3):1135-1158. doi: [6] Ehninger D, Neff F, Xie K. Longevity, aging and rapamycin. Cell Mol Life Sci. 2014;71(22):4325-4346. doi: [7] Ehninger D, Neff F, Xie K. Longevity, aging and rapamycin. Cell Mol Life Sci. 2014;71(22):4325-4346. doi: [8] Dorling JL, Martin CK, Redman LM. Calorie restriction for enhanced longevity: The role of novel dietary strategies in the present obesogenic environment. Ageing Res Rev. 2020;64:101038. doi: [9] Zia A, Farkhondeh T, Pourbagher-Shahri AM, Samarghandian S. The role of curcumin in aging and senescence: Molecular mechanisms. Biomed Pharmacother. 2021;134:111119. doi: [10] Xu M, Pirtskhalava T, Farr JN, et al. Senolytics improve physical function and increase lifespan in old age. Nat Med. 2018;24(8):1246-1256. doi: [11] Kowald A, Kirkwood TBL. Senolytics and the compression of late-life mortality. Exp Gerontol. 2021;155:111588. doi: [12] Yousefzadeh MJ, Zhu Y, McGowan SJ, et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018;36:18-28. doi: #antiaging #antiagingtreatment #agingbackwards ********CRITIQUES, RULES, AND NOTES******** Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique: Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached. RULES: If your comment is rude, you will be banned without warning. If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, your comment will be ignored. If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it. Please use the following link to submit your critique: Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.
