Guest
Like this video? Sign up now on our website at to access 800 Exclusive videos on Basic Medical Sciences & Clinical Medicine. These are premium videos (NOT FROM YOUTUBE). All these videos come with English subtitles & download options. Sign up now! Get Lifetime Access for a one-time payment of $99 ONLY! Why sign up for premium membership? Here's why! Membership Features for premium website members. 1. More than 800 Medical Lectures. 2. Basic Medical Sciences & Clinical Medicine. 3. Mobile-friendly interface with android and iOS apps. 4. English subtitles and new videos every week. 5. Download option for offline video playback. 6. Fanatic customer support and that's 24/7. 7. Fast video playback option to learn faster. 8. Trusted by over 2M students in 190 countries. Each kidney has more than a million nephrons and therefore Glomeruli. Efferent and Afferent arterioles take blood to & from these glomeruli & together form Glomerular Capillaries on top of Bowman's Capsule of Glomerulus. Glomerular Basement Membrane (GBM) separates the glomerular capillaries from the Bowman's capsule. Together endothelial cells of glomerular capillaries, GBM & visceral epithelial cells of Bowman's capsule (particularly the foot processes) make up the filtration barrier that is central to the functioning of nephron. In addition to size filtration, there also exists a 'charge filtration' mechanism; owing to the overwhelming negative charges on endothelial cells, GBM and visceral epithelial cells. Clinical Co-relate; in fact, there is a disease called Minimal Change Glomerulopathy (MCG) in which breakdown of filtration mechanism is not owing to any structural alteration of filtration membrane but in fact neutralization of negative charges on the filtration membrane.
