The science of the CUE1

The CUE1 utilises pulsed cueing and focused vibrotactile stimulation to alleviate symptoms including slowness, stiffness, and freezing of gait, resulting in improved movement. In this animation we explore the best current understanding of how the CUE1 works. With special thanks for the EAHSN for supporting the production of this animation. References from this video: Schuepbach, W. M. M. et al. Neurostimulation for Parkinson's Disease with early motor complications. New England Journal of Medicine 368, 610–622 (2013). Fischbach, G. D. & McKhann, G. M. Cell therapy for Parkinson's Disease. New England Journal of Medicine 344, 763–765 (2001). Little, S. & Brown, P. The functional role of beta oscillations in Parkinson's Disease. Parkinsonism & Related Disorders 20, Suppl 1 S44-8 (2014). Macerollo, A. et al. High‐frequency peripheral vibration decreases completion time on a number of motor tasks. European Journal of Neuroscience 48, 1789-1802 (2018). Friston, K., Mattout, J. & Kilner, J. Action understanding and active inference. Biological Cybernetics 104, 137-160 (2011). Voltaire & Astruc. La chaire trepidante. La France Medicale 578–581 (1892). Goetz, C. G. Jean-Martin Charcot and his vibratory chair for Parkinson disease. Neurology 73, 475–478 (2009). Goetz C. G. & Bonduelle as therapeutic interventionist and treating neurologist. Historical Neurology 45 (11). (1995). Haas, C. et al. The effects of random whole-body-vibration on motor symptoms in Parkinson's disease. NeuroRehabilitation 21, 29-36 (2006). Kröger, S. & Watkins, B. Muscle spindle function in healthy and diseased muscle. Skeletal Muscle 11,1-13 (2021). Macerollo, A. et al. High‐frequency peripheral vibration decreases completion time on a number of motor tasks. European Journal of Neuroscience 48, 1789–1802 (2018). Cui, C. & Lewis, S. Future Therapeutic Strategies for Freezing of Gait in Parkinson’s Disease. Frontiers in Human Neuroscience (2021). Tan X. S., et al. Focused Vibrotactile Stimulation with Cueing Effect on Freezing of Gait in Parkinson’s Disease. Journal of Movement Disorders 14(3): 236-238. (2021) Ghai, S., Ghai, I., Schmitz, G. & Effenberg, A. O. Effect of rhythmic auditory cueing on Parkinsonian Gait: A systematic review and meta-analysis. Scientific Reports 8, 1-19 (2018). #Parkinsons #Charco #Community #Collaboration #Innovation #Design #MedTech #CUE1 #Tremor #Symptoms #Results #science Rutz, D. & Benninger, D. Physical Therapy for Freezing of Gait and Gait Impairments in Parkinson Disease: A Systematic Review. PM&R 12, 1140-1156 (2020). Baker, K. et al. The Immediate Effect of Attentional, Auditory, and a Combined Cue Strategy on Gait During Single and Dual Tasks in Parkinson’s Disease. Archives of Physical Medicine and Rehabilitation 88, 1593-1600 (2007). Baker, K. et al. The effect of cues on gait variability—Reducing the attentional cost of walking in people with Parkinson's disease. Parkinsonism & Related Disorders 14, 314-320 (2008). Tessitore, A., Giordano, A., De Micco, R., Russo, A. & Tedeschi, G. Sensorimotor Connectivity in Parkinson's Disease: The Role of Functional Neuroimaging. Frontiers in Neurology 5, (2014). Rubin, J., McIntyre, C., Turner, R. & Wichmann, T. Basal ganglia activity patterns in parkinsonism and computational modeling of their downstream effects. European Journal of Neuroscience 36, 2213-2228 (2012).